Modern Family Season 3 dvd release led the 18th annual Screen Actors Guild nominations Thursday with five mentions, as the sitcom's cast will look to defend its comedy ensemble crown.

The show will vie for ensemble honors against Glee, The Office Seasons 1-7 DVD Boxset, 30 Rock and The Big Bang Theory, which broke into the category for the first time.

Four Modern Family cast members — Sofia Vergara and Emmy winners Julie Bowen, Ty Burrell and Eric Stonestreet — picked up acting nominations.

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Vergara and Bowen are up against three-time champ Tina Fey (30 Rock Seasons 1-5 DVD), defending champ Betty White (Hot in Cleveland) and Edie Falco (Nurse Jackie). Burrell and Stonestreet's competition include Steve Carell (The Office), Jon Cryer (Two and a Half Men) and Alec Baldwin (30 Rock), who will go for an unprecedented six-peat in the comedy actor race.

In drama, two-time reigning champ Julianna Margulies (The Good Wife Season 3 dvd release) — already SAG's winningest performer with eight trophies — will try to defend her drama actress title against Glenn Close (Damages), Kathy Bates (Harry's Law), Jessica Lange (American Horror Story) and Kyra Sedgwick (The Closer).

The drama actor category pits reigning champ Steve Buscemi (Boardwalk Empire) against Bryan Cranston (Breaking Bad), Kyle Chandler (Friday Night Lights), Michael C. Hall (Dexter) and, in a surprise, Patrick J. Adams (Suits).

Boardwalk's ensemble will go for a repeat win against the casts of Breaking Bad, Game of Thrones, Dexter and The Good Wife.

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In film, The Help scored four nominations, including in ensemble nod, where it will face off against the casts of  The Artist, Bridesmaids, The Descendants and Midnight in Paris.

The 18th annual Screen Actors Guild Awards will air live Sunday, Jan. 29 at 8/7c on TNT and TBS.